AKo drops from the 4-bet range — deep, it would rather see a flop than get the stacks in drawing at six outs when behind.
AK begins migrating from 4-bet to call — stacking off 200bb with one-pair hands is no longer automatic.
You opened middle, the cutoff 3-bet with position. Their range is wider than a blind's — your response widens to match.
Assumes a standard 3-bet; 4-bet to ~2.2–2.5x the 3-bet. Deep, favor calls over 4-bets — a 4-bet pot at 500bb+ commits you with range disadvantage.