Position lets the suited peels breathe; the 4-bet range starts its long deep-stack retreat.
AK begins migrating from 4-bet to call — stacking off 200bb with one-pair hands is no longer automatic.
The big blind 3-bets your middle open. Out-of-position 3-bets skew honest — adjust your continues accordingly, and enjoy position all hand.
Assumes a standard 3-bet; 4-bet to ~2.2–2.5x the 3-bet. Deep, favor calls over 4-bets — a 4-bet pot at 500bb+ commits you with range disadvantage.