A standard live response: premium 4-bets, solid calls, honest folds.
The reference tier. 4-bet a tight value range, call with hands that flop well, fold the rest without ceremony.
You opened middle, the cutoff 3-bet with position. Their range is wider than a blind's — your response widens to match.
Assumes a standard 3-bet; 4-bet to ~2.2–2.5x the 3-bet. Deep, favor calls over 4-bets — a 4-bet pot at 500bb+ commits you with range disadvantage.