You have position for the whole hand — use it to peel the nut-potential suited hands a 100bb stack could not justify.
AK begins migrating from 4-bet to call — stacking off 200bb with one-pair hands is no longer automatic.
The big blind 3-bets your early open from out of position — a range that is almost always dense with value.
Assumes a standard 3-bet; 4-bet to ~2.2–2.5x the 3-bet. Deep, favor calls over 4-bets — a 4-bet pot at 500bb+ commits you with range disadvantage.