The standard 200bb shift: more set-mining, more suited peels, fewer manufactured big pots.
AK begins migrating from 4-bet to call — stacking off 200bb with one-pair hands is no longer automatic.
The big blind 3-bets your cutoff steal. The discount made their call cheap — the 3-bet means they chose not to take it.
Assumes a standard 3-bet; 4-bet to ~2.2–2.5x the 3-bet. Deep, favor calls over 4-bets — a 4-bet pot at 500bb+ commits you with range disadvantage.