The 4-bet bluffs retire at 200bb — depth punishes manufactured big pots out of position.
AK begins migrating from 4-bet to call — stacking off 200bb with one-pair hands is no longer automatic.
The button 3-bets your hijack open — its favorite move with its favorite weapon, position.
Assumes a standard 3-bet; 4-bet to ~2.2–2.5x the 3-bet. Deep, favor calls over 4-bets — a 4-bet pot at 500bb+ commits you with range disadvantage.