AKo joins the calls, the pairs multiply, and the plan is the same as every deep spot: flop it or fold it.
AK begins migrating from 4-bet to call — stacking off 200bb with one-pair hands is no longer automatic.
The big blind 3-bets your button open instead of taking the discount — a move that announces a real hand or a real plan.
Assumes a standard 3-bet; 4-bet to ~2.2–2.5x the 3-bet. Deep, favor calls over 4-bets — a 4-bet pot at 500bb+ commits you with range disadvantage.