The suited hands with nut potential start peeling — 200bb of implied odds against a range that will pay them off.
AK begins migrating from 4-bet to call — stacking off 200bb with one-pair hands is no longer automatic.
You opened early and got 3-bet by the player right behind you — the most credible 3-bet in poker. Respect it.
Assumes a standard 3-bet; 4-bet to ~2.2–2.5x the 3-bet. Deep, favor calls over 4-bets — a 4-bet pot at 500bb+ commits you with range disadvantage.