Position plus depth: the peels widen while the 4-bets thin — the recurring deep-stack theme.
AK begins migrating from 4-bet to call — stacking off 200bb with one-pair hands is no longer automatic.
The small blind 3-bets your cutoff open — a range built to play fast, because playing slow out of position deep is misery.
Assumes a standard 3-bet; 4-bet to ~2.2–2.5x the 3-bet. Deep, favor calls over 4-bets — a 4-bet pot at 500bb+ commits you with range disadvantage.