Every pair peels for the set at 200bb; AKo takes the passive line and keeps the pot honest.
AK begins migrating from 4-bet to call — stacking off 200bb with one-pair hands is no longer automatic.
A middle open meets a button 3-bet — the widest, most leveraged 3-bet you will face, armed with position.
Assumes a standard 3-bet; 4-bet to ~2.2–2.5x the 3-bet. Deep, favor calls over 4-bets — a 4-bet pot at 500bb+ commits you with range disadvantage.