Wheel aces join the defense — hands that can make the nuts and fold everything else without a second thought.
4-betting narrows to the very top; suited hands with nut potential call more. The question on every street becomes: which hands are happy getting 500bb in?
A middle open meets a button 3-bet — the widest, most leveraged 3-bet you will face, armed with position.
Assumes a standard 3-bet; 4-bet to ~2.2–2.5x the 3-bet. Deep, favor calls over 4-bets — a 4-bet pot at 500bb+ commits you with range disadvantage.