A blind-versus-open 3-bet into an EP range means business. 4-bet kings-plus, call the compact top, fold the rest.
The reference tier. 4-bet a tight value range, call with hands that flop well, fold the rest without ceremony.
The big blind 3-bets your early open from out of position — a range that is almost always dense with value.
Assumes a standard 3-bet; 4-bet to ~2.2–2.5x the 3-bet. Deep, favor calls over 4-bets — a 4-bet pot at 500bb+ commits you with range disadvantage.