In position 500bb deep, nearly the whole playable range prefers calling — initiative means little when stacks are this tall.
4-betting narrows to the very top; suited hands with nut potential call more. The question on every street becomes: which hands are happy getting 500bb in?
The big blind 3-bets your hijack steal from the worst seat at the table — a range heavy with hands that mean it.
Assumes a standard 3-bet; 4-bet to ~2.2–2.5x the 3-bet. Deep, favor calls over 4-bets — a 4-bet pot at 500bb+ commits you with range disadvantage.