Even against the button's width, 500bb out of position demands restraint: raise the top, call the nutted, fold the pretty.
The 3-bet range condenses toward hands that welcome a giant pot; almost everything else that plays well flats. Bloated pots with dominated hands are how 500bb stacks vanish.
The button opens into the blinds nearly half the time. The small blind's answer is an aggressive, 3-bet-first defense — flatting here plays a guessing game out of position against the widest range in poker.
Assumes a ~4bb open; 3-bet to ~3x the open in position, ~4x from the blinds — larger as stacks deepen.