Only KK+ builds the pot. Everything else — including AKs — would rather see a flop than face a 4-bet decision for a fortune.
3-betting is nearly reserved for the top of the deck. Position and nut potential dictate everything else; offsuit broadways are mostly gone.
The tightest confrontation at the table: an early open, and you right behind it with six players still to act.
Assumes a ~4bb open; 3-bet to ~3x the open in position, ~4x from the blinds — larger as stacks deepen.